Runx2 Association with Progression of Prostate Cancer in Patients: Mechanisms Mediating Bone Osteolysis and Osteoblastic Metastatic Lesions

Runx2, a bone-specific transcriptional regulator, is abnormally expressed in highly metastatic prostate cancer cells. Here we identified the functional activities of Runx2 in facilitating tumor growth and osteolysis. Our studies demonstrate that negligible Runx2 is found in normal prostate epithelia...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Akech, Jacqueline, Wixted, John J., Bedard, Krystin, van der Deen, Margaretha, Hussain, Sadiq, Guise, Theresa A., van Wijnen, Andre J., Stein, Janet L., Languino, Lucia R., Altieri, Dario C., Pratap, Jitesh, Keller, Evan, Stein, Gary S., Lian, Jane B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820596/
https://ncbi.nlm.nih.gov/pubmed/19915614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.389
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge