Runx2-Smad signaling impacts the progression of tumor-induced bone disease

Runx2, a master regulator of osteogenesis, is abnormally expressed in advanced prostate cancer. Here we addressed Runx2 contribution to formation of prostate cancer-related osteolytic and osteoblastic bone lesions by mediating TGFβ/BMP signaling through direct interaction with Smads. Further, we exa...

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Vydáno v:Int J Cancer
Hlavní autoři: Zhang, Xuhui, Akech, Jacqueline, Browne, Gillian, Russell, Stacey, Wixted, John J., Stein, Janet L., Stein, Gary S., Lian, Jane B.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4289427/
https://ncbi.nlm.nih.gov/pubmed/25053011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.29094
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