Silencing BMI1 eliminates tumor formation of pediatric glioma CD133+ cells not by affecting known targets but by down-regulating a novel set of core genes

Clinical outcome of children with malignant glioma remains dismal. Here, we examined the role of over-expressed BMI1, a regulator of stem cell self-renewal, in sustaining tumor formation in pediatric glioma stem cells. Our investigation revealed BMI1 over-expression in 29 of 54 (53.7%) pediatric gli...

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Bibliografiske detaljer
Udgivet i:Acta Neuropathol Commun
Main Authors: Baxter, Patricia A, Lin, Qi, Mao, Hua, Kogiso, Mari, Zhao, Xiumei, Liu, Zhigang, Huang, Yulun, Voicu, Horatiu, Gurusiddappa, Sivashankarappa, Su, Jack M, Adesina, Adekunle M, Perlaky, Laszlo, Dauser, Robert C, Leung, Hon-chiu Eastwood, Muraszko, Karin M, Heth, Jason A, Fan, Xing, Lau, Ching C, Man, Tsz-Kwong, Chintagumpala, Murali, Li, Xiao-Nan
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4289398/
https://ncbi.nlm.nih.gov/pubmed/25526772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-014-0160-4
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