Silencing BMI1 eliminates tumor formation of pediatric glioma CD133+ cells not by affecting known targets but by down-regulating a novel set of core genes

Clinical outcome of children with malignant glioma remains dismal. Here, we examined the role of over-expressed BMI1, a regulator of stem cell self-renewal, in sustaining tumor formation in pediatric glioma stem cells. Our investigation revealed BMI1 over-expression in 29 of 54 (53.7%) pediatric gli...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Baxter, Patricia A, Lin, Qi, Mao, Hua, Kogiso, Mari, Zhao, Xiumei, Liu, Zhigang, Huang, Yulun, Voicu, Horatiu, Gurusiddappa, Sivashankarappa, Su, Jack M, Adesina, Adekunle M, Perlaky, Laszlo, Dauser, Robert C, Leung, Hon-chiu Eastwood, Muraszko, Karin M, Heth, Jason A, Fan, Xing, Lau, Ching C, Man, Tsz-Kwong, Chintagumpala, Murali, Li, Xiao-Nan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4289398/
https://ncbi.nlm.nih.gov/pubmed/25526772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-014-0160-4
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