A clinically relevant orthotopic xenograft model of ependymoma that maintains the genomic signature of the primary tumor and preserves cancer stem cells in vivo

Limited availability of in vitro and in vivo model systems has hampered efforts to understand tumor biology and test novel therapies for ependymoma, the third most common malignant brain tumor that occurs in children. To develop clinically relevant animal models of ependymoma, we directly injected a...

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Opis bibliograficzny
Główni autorzy: Yu, Litian, Baxter, Patricia A., Voicu, Horatiu, Gurusiddappa, Sivashankarappa, Zhao, Yijue, Adesina, Adekunle, Man, Tsz-Kwong, Shu, Qin, Zhang, Yu-Jing, Zhao, Xiu-Mei, Su, Jack M., Perlaky, Lazlo, Dauser, Robert, Chintagumpala, Murali, Lau, Ching C., Blaney, Susan M., Rao, Pulivarthi H., Leung, Hon-chiu Eastwood, Li, Xiao-Nan
Format: Artigo
Język:Inglês
Wydane: Oxford University Press 2010
Hasła przedmiotowe:
Basic and Translational Investigations
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940646/
https://ncbi.nlm.nih.gov/pubmed/20511191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nop056
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