Intravenous injection of oncolytic picornavirus SVV-001 prolongs animal survival in a panel of primary tumor–based orthotopic xenograft mouse models of pediatric glioma

BACKGROUND: Seneca Valley virus (SVV-001) is a nonpathogenic oncolytic virus that can be systemically administered and can pass through the blood–brain barrier. We examined its therapeutic efficacy and the mechanism of tumor cell infection in pediatric malignant gliomas. METHODS: In vitro antitumor...

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Detalhes bibliográficos
Main Authors: Liu, Zhigang, Zhao, Xiumei, Mao, Hua, Baxter, Patricia A., Huang, Yulun, Yu, Litian, Wadhwa, Lalita, Su, Jack M., Adesina, Adekunle, Perlaky, Lazlo, Hurwitz, Mary, Idamakanti, Neeraja, Police, Seshidhar Reddy, Hallenbeck, Paul L., Hurwitz, Richard L., Lau, Ching C., Chintagumpala, Murali, Blaney, Susan M., Li, Xiao-Nan
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3748915/
https://ncbi.nlm.nih.gov/pubmed/23658322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/not065
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