Phase I Clinical Study of Seneca Valley Virus (SVV-001), a Replication-Competent Picornavirus, in Advanced Solid Tumors with Neuroendocrine Features

PURPOSE: Seneca Valley Virus (SVV-001) is a novel naturally occurring replication-competent picornavirus with potent and selective tropism for neuroendocrine cancer cell types, including small cell lung cancer. We conducted a first-in-human, first-in-class phase I clinical trial of this agent in pat...

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Bibliographic Details
Published in:Clin Cancer Res
Main Authors: Rudin, Charles M., Poirier, John T., Senzer, Neil N., Stephenson, Joseph, Loesch, David, Burroughs, Kevin D., Reddy, P. Seshidhar, Hann, Christine L., Hallenbeck, Paul L.
Format: Artigo
Language:Inglês
Published: 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5317273/
https://ncbi.nlm.nih.gov/pubmed/21304001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-1706
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