Intravenous injection of oncolytic picornavirus SVV-001 prolongs animal survival in a panel of primary tumor–based orthotopic xenograft mouse models of pediatric glioma

BACKGROUND: Seneca Valley virus (SVV-001) is a nonpathogenic oncolytic virus that can be systemically administered and can pass through the blood–brain barrier. We examined its therapeutic efficacy and the mechanism of tumor cell infection in pediatric malignant gliomas. METHODS: In vitro antitumor...

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Hlavní autoři: Liu, Zhigang, Zhao, Xiumei, Mao, Hua, Baxter, Patricia A., Huang, Yulun, Yu, Litian, Wadhwa, Lalita, Su, Jack M., Adesina, Adekunle, Perlaky, Lazlo, Hurwitz, Mary, Idamakanti, Neeraja, Police, Seshidhar Reddy, Hallenbeck, Paul L., Hurwitz, Richard L., Lau, Ching C., Chintagumpala, Murali, Blaney, Susan M., Li, Xiao-Nan
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2013
Témata:
Basic and Translational Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3748915/
https://ncbi.nlm.nih.gov/pubmed/23658322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/not065
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