Transgenic Expression of CXCR3 on T Cells Enhances Susceptibility to Cutaneous Leishmania major Infection by Inhibiting Monocyte Maturation and Promoting a Th2 Response

Cutaneous leishmaniasis, caused mainly by Leishmania major, an obligate intracellular parasite, is a disfiguring disease characterized by large skin lesions and is transmitted by a sand fly vector. We previously showed that the chemokine receptor CXCR3 plays a critical role in mediating resistance t...

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Veröffentlicht in:Infect Immun
Hauptverfasser: Oghumu, Steve, Stock, James C., Varikuti, Sanjay, Dong, Ran, Terrazas, Cesar, Edwards, Jessica A., Rappleye, Chad A., Holovatyk, Ariel, Sharpe, Arlene, Satoskar, Abhay R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2014
Schlagworte:
Fungal and Parasitic Infections
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4288897/
https://ncbi.nlm.nih.gov/pubmed/25312956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02540-14
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