MicroRNA155 Plays a Critical Role in the Pathogenesis of Cutaneous Leishmania major Infection by Promoting a Th2 Response and Attenuating Dendritic Cell Activity

Interferon (IFN)-γ is indispensable in the resolution of cutaneous leishmaniasis (CL), while the Th2 cytokines IL-4, IL-10, and IL-13 mediate susceptibility. A recent study found that miR155, which promotes CD4(+) Th1 response and IFN-γ production, is dispensable in the control of Leishmania donovan...

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Bibliografiske detaljer
Udgivet i:Am J Pathol
Main Authors: Varikuti, Sanjay, Verma, Chaitenya, Natarajan, Gayathri, Oghumu, Steve, Satoskar, Abhay R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2021
Fag:
Short Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8132173/
https://ncbi.nlm.nih.gov/pubmed/33539779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2021.01.012
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