MicroRNA 155 Contributes to Host Immunity against Leishmania donovani but Is Not Essential for Resolution of Infection

CD4(+) T helper 1 (Th1) cells producing interferon gamma (IFN-γ) are critical for the resolution of visceral leishmaniasis (VL). MicroRNA 155 (miR155) promotes CD4(+) Th1 responses and IFN-γ production by targeting suppressor of cytokine signaling-1 (SOCS1) and Src homology-2 domain-containing inosi...

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Udgivet i:Infect Immun
Main Authors: Varikuti, Sanjay, Natarajan, Gayathri, Volpedo, Greta, Singh, Bhawana, Hamza, Omar, Messick, Gretchen V., Guerau-de-Arellano, Mireia, Papenfuss, Tracey L., Oghumu, Steve, Satoskar, Abhay R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2019
Fag:
Fungal and Parasitic Infections
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6652779/
https://ncbi.nlm.nih.gov/pubmed/31182615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00307-19
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