Persistence and Toxin Production by Clostridium difficile within Human Intestinal Organoids Result in Disruption of Epithelial Paracellular Barrier Function

Clostridium difficile is the leading cause of infectious nosocomial diarrhea. The pathogenesis of C. difficile infection (CDI) results from the interactions between the pathogen, intestinal epithelium, host immune system, and gastrointestinal microbiota. Previous studies of the host-pathogen interac...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Leslie, Jhansi L., Huang, Sha, Opp, Judith S., Nagy, Melinda S., Kobayashi, Masayuki, Young, Vincent B., Spence, Jason R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Host Response and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4288864/
https://ncbi.nlm.nih.gov/pubmed/25312952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02561-14
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