Systems Level Analysis of Systemic Sclerosis Shows a Network of Immune and Profibrotic Pathways Connected with Genetic Polymorphisms

Systemic sclerosis (SSc) is a rare systemic autoimmune disease characterized by skin and organ fibrosis. The pathogenesis of SSc and its progression are poorly understood. The SSc intrinsic gene expression subsets (inflammatory, fibroproliferative, normal-like, and limited) are observed in multiple...

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Foilsithe in:PLoS Comput Biol
Main Authors: Mahoney, J. Matthew, Taroni, Jaclyn, Martyanov, Viktor, Wood, Tammara A., Greene, Casey S., Pioli, Patricia A., Hinchcliff, Monique E., Whitfield, Michael L.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2015
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4288710/
https://ncbi.nlm.nih.gov/pubmed/25569146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004005
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