Novel antitumor mechanism-of-action of an IL-2 fusion protein mediated by tumor associated macrophage repolarization and innate-like CD8+ memory T cells

Ítems similars

• A Novel Fusion of ALT-803 (Interleukin (IL)-15 Superagonist) with an Antibody Demonstrates Antigen-specific Antitumor Responses
  per: Liu, Bai, et al.
  Publicat: (2016)
• Evaluation of a novel CD20-targeted IL-15 immunotherapeutic with potent activity against B cell lymphoma
  per: Liu, Bai, et al.
  Publicat: (2014)
• Combination therapy of an IL-15 superagonist complex, ALT-803, and a tumor targeting monoclonal antibody promotes direct antitumor activity and protective vaccinal effect in a syngenic mouse melanoma model
  per: Chen, Xiaoyue, et al.
  Publicat: (2015)
• The IL-15-based superagonist ALT-803 promotes the antigen-independent conversion of memory CD8(+) T cells into innate-like effector cells with antitumor activity
  per: Wong, Hing C, et al.
  Publicat: (2013)
• Comparison of the super agonist complex, ALT-803, to IL-15 as cancer immunotherapeutics in animal models
  per: Rhode, Peter R., et al.
  Publicat: (2015)