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Hypothesis: cell signalling influences age-related risk of colorectal cancer

We propose that ageing is linked to colonic carcinogenesis through crosstalk between Wnt activity and signalling pathways related to ageing and senescence: progerin, klotho and mTOR. Mutations in the Wnt signalling pathway are responsible for the majority of colorectal cancers (CRCs); however, hyper...

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Dades bibliogràfiques
Publicat a:J Cell Mol Med
Autors principals: Bordonaro, Michael, Lazarova, Darina L
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4288351/
https://ncbi.nlm.nih.gov/pubmed/25388238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.12366
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