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Hypothesis: cell signalling influences age-related risk of colorectal cancer
We propose that ageing is linked to colonic carcinogenesis through crosstalk between Wnt activity and signalling pathways related to ageing and senescence: progerin, klotho and mTOR. Mutations in the Wnt signalling pathway are responsible for the majority of colorectal cancers (CRCs); however, hyper...
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| Publicado no: | J Cell Mol Med |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Publishing Ltd
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4288351/ https://ncbi.nlm.nih.gov/pubmed/25388238 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.12366 |
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