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Flexibility and structural conservation in a c-KIT G-quadruplex

A quadruplex sequence from the promoter region of the c-KIT gene forms a stable quadruplex, as characterized by crystallographic and NMR methods. Two new crystal structures are reported here, together with molecular dynamics simulation studies on these quadruplex crystal structures and an NMR struct...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Wei, Dengguo, Husby, Jarmila, Neidle, Stephen
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4288176/
https://ncbi.nlm.nih.gov/pubmed/25452341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1282
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