Meclofenamic acid selectively inhibits FTO demethylation of m(6)A over ALKBH5

Two human demethylases, the fat mass and obesity-associated (FTO) enzyme and ALKBH5, oxidatively demethylate abundant N(6)-methyladenosine (m(6)A) residues in mRNA. Achieving a method for selective inhibition of FTO over ALKBH5 remains a challenge, however. Here, we have identified meclofenamic acid...

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Publicat a:Nucleic Acids Res
Autors principals: Huang, Yue, Yan, Jingli, Li, Qi, Li, Jiafei, Gong, Shouzhe, Zhou, Hu, Gan, Jianhua, Jiang, Hualiang, Jia, Gui-Fang, Luo, Cheng, Yang, Cai-Guang
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2015
Matèries:
Molecular Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4288171/
https://ncbi.nlm.nih.gov/pubmed/25452335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1276
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