L-2-Hydroxyglutarate: An Epigenetic Modifier and Putative Oncometabolite in Renal Cancer

Through unbiased metabolomics, we identified elevations of the metabolite 2-hydroxyglutarate (2HG) in renal cell carcinoma (RCC). 2HG can inhibit 2-oxoglutaratre (2-OG) dependent dioxygenases which mediate epigenetic events including DNA and histone demethylation. 2HG accumulation, specifically the...

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Veröffentlicht in:Cancer Discov
Hauptverfasser: Shim, Eun-Hee, Livi, Carolina B., Rakheja, Dinesh, Tan, Jubilee, Benson, Daniel, Parekh, Vishwas, Kho, Eun-Young, Ghosh, Arindam P., Kirkman, Richard, Velu, Sadanan, Dutta, Shilpa, Chenna, Balachandra, Rea, Shane L, Mishur, Robert J, Li, Qiuhua, Johnson-Pais, Teresa L., Guo, Lining, Bae, Sejong, Wei, Shi, Block, Karen, Sudarshan, Sunil
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4286872/
https://ncbi.nlm.nih.gov/pubmed/25182153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-0696
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