Probing Binding Sites and Mechanisms of Action of an I(Ks) Activator by Computations and Experiments

The slow delayed rectifier (I(Ks)) channel is composed of the KCNQ1 channel and KCNE1 auxiliary subunit, and functions to repolarize action potentials in the human heart. I(Ks) activators may provide therapeutic efficacy for treating long QT syndromes. Here, we show that a new KCNQ1 activator, ML277...

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Bibliografiske detaljer
Udgivet i:Biophys J
Main Authors: Xu, Yu, Wang, Yuhong, Zhang, Mei, Jiang, Min, Rosenhouse-Dantsker, Avia, Wassenaar, Tsjerk, Tseng, Gea-Ny
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2015
Fag:
Channels and Transporters
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4286593/
https://ncbi.nlm.nih.gov/pubmed/25564853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.10.059
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