Probing Binding Sites and Mechanisms of Action of an I(Ks) Activator by Computations and Experiments

The slow delayed rectifier (I(Ks)) channel is composed of the KCNQ1 channel and KCNE1 auxiliary subunit, and functions to repolarize action potentials in the human heart. I(Ks) activators may provide therapeutic efficacy for treating long QT syndromes. Here, we show that a new KCNQ1 activator, ML277...

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Bibliografske podrobnosti
izdano v:Biophys J
Main Authors: Xu, Yu, Wang, Yuhong, Zhang, Mei, Jiang, Min, Rosenhouse-Dantsker, Avia, Wassenaar, Tsjerk, Tseng, Gea-Ny
Format: Artigo
Jezik:Inglês
Izdano: The Biophysical Society 2015
Teme:
Channels and Transporters
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4286593/
https://ncbi.nlm.nih.gov/pubmed/25564853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.10.059
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