Autophagy mediates HIF2α degradation and suppresses renal tumorigenesis

Autophagy is a conserved process involved in lysosomal degradation of protein aggregates and damaged organelles. The role of autophagy in cancer is a topic of intense debate, and the underlying mechanism is still not clear. The hypoxia inducible factor 2α (HIF2α), an oncogenic transcription factor i...

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Publicat a:Oncogene
Autors principals: Liu, Xian-De, Yao, Jun, Tripathi, Durga Nand, Ding, Zhiyong, Xu, Yi, Sun, Mianen, Zhang, Jiangwei, Bai, Shanshan, German, Peter, Hoang, Anh, Zhou, Lijun, Jonasch, Darius, Zhang, Xuesong, Conti, Claudio J., Efstathiou, Eleni, Tannir, Nizar M, Eissa, N. Tony, Mills, Gordon B., Walker, Cheryl Lyn, Jonasch, Eric
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4286517/
https://ncbi.nlm.nih.gov/pubmed/24998849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.199
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