Resistance to anti-angiogenic therapy is associated with an immunosuppressive tumor microenvironment in metastatic renal cell carcinoma

Renal cell carcinoma (RCC) is an immunogenic and proangiogenic cancer, and anti-angiogenic therapy is the current mainstay of treatment. RCC patients develop innate or adaptive resistance to anti-angiogenic therapy. There is a need to identify biomarkers that predict therapeutic resistance and guide...

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Gepubliceerd in:Cancer Immunol Res
Hoofdauteurs: Liu, Xian-De, Hoang, Anh, Zhou, Lijun, Kalra, Sarathi, Yetil, Alper, Sun, Mianen, Ding, Zhiyong, Zhang, Xuesong, Bai, Shanshan, German, Peter, Tamboli, Pheroze, Rao, Priya, Karam, Jose A, Wood, Christopher, Matin, Surena, Zurita, Amado, Bex, Axel, Griffioen, Arjan W., Gao, Jianjun, Sharma, Padmanee, Tannir, Nizar, Sircar, Kanishka, Jonasch, Eric
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4561186/
https://ncbi.nlm.nih.gov/pubmed/26014097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-14-0244
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