LASP1 is a HIF-1α target gene critical for metastasis of pancreatic cancer

LASP1 is an actin-binding protein associated with actin assembly dynamics in cancer cells. Here we report that LASP1 is overexpressed in pancreatic ductal adenocarcinoma (PDAC) where it promotes invasion and metastasis. We found that LASP1 overexpression in PDAC cells was mediated by HIF-1α through...

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Veröffentlicht in:Cancer Res
Hauptverfasser: Zhao, Tiansuo, Ren, He, Li, Jing, Chen, Jing, Zhang, Huan, Xin, Wen, Sun, Yan, Sun, Lei, Yang, Yongwei, Sun, Junwei, Wang, Xiuchao, Gao, Song, Huang, Chongbiao, Zhang, Huafeng, Yang, Shengyu, Hao, Jihui
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4286473/
https://ncbi.nlm.nih.gov/pubmed/25385028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-2040
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