Tumour-derived Interleukin 35 promotes pancreatic ductal adenocarcinoma cell extravasation and metastasis by inducing ICAM1 expression

Interleukin 35 (IL-35) is a novel member of the IL-12 family, consisting of an EBV-induced gene 3 (EBI3) subunit and a P35 subunit. IL-35 is an immune-suppressive cytokine mainly produced by regulatory T cells. However, the role of IL-35 in cancer metastasis and progression is not well understood. H...

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Vydáno v:Nat Commun
Hlavní autoři: Huang, Chongbiao, Li, Na, Li, Zengxun, Chang, Antao, Chen, Yanan, Zhao, Tiansuo, Li, Yang, Wang, Xiuchao, Zhang, Wei, Wang, Zhimin, Luo, Lin, Shi, Jingjing, Yang, Shengyu, Ren, He, Hao, Jihui
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5253665/
https://ncbi.nlm.nih.gov/pubmed/28102193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14035
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