FadA5 a thiolase from Mycobacterium tuberculosis - a unique steroid-binding pocket reveals the potential for drug development against tuberculosis

With the exception of HIV, tuberculosis (TB) is the leading cause of mortality among infectious diseases. The urgent need to develop new anti-tubercular drugs is apparent due to the increasing number of drug resistant Mycobacterium tuberculosis (Mtb) strains. Proteins involved in cholesterol import...

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Bibliografiske detaljer
Udgivet i:Structure
Main Authors: Schaefer, Christin M., Lu, Rui, Nesbitt, Natasha M., Schiebel, Johannes, Sampson, Nicole S., Kisker, Caroline
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4286435/
https://ncbi.nlm.nih.gov/pubmed/25482540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2014.10.010
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