A Thiolase of Mycobacterium tuberculosis Is Required for Virulence and Production of Androstenedione and Androstadienedione from Cholesterol

Mycobacterium tuberculosis, the causative agent of tuberculosis, is an intracellular pathogen that shifts to a lipid-based metabolism in the host. Moreover, metabolism of the host lipid cholesterol plays an important role in M. tuberculosis infection. We used transcriptional profiling to identify ge...

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Autors principals: Nesbitt, Natasha M., Yang, Xinxin, Fontán, Patricia, Kolesnikova, Irina, Smith, Issar, Sampson, Nicole S., Dubnau, Eugenie
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2010
Matèries:
Bacterial Infections
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798224/
https://ncbi.nlm.nih.gov/pubmed/19822655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00893-09
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