FadA5 a thiolase from Mycobacterium tuberculosis - a unique steroid-binding pocket reveals the potential for drug development against tuberculosis

With the exception of HIV, tuberculosis (TB) is the leading cause of mortality among infectious diseases. The urgent need to develop new anti-tubercular drugs is apparent due to the increasing number of drug resistant Mycobacterium tuberculosis (Mtb) strains. Proteins involved in cholesterol import...

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Detalles Bibliográficos
Publicado en:Structure
Main Authors: Schaefer, Christin M., Lu, Rui, Nesbitt, Natasha M., Schiebel, Johannes, Sampson, Nicole S., Kisker, Caroline
Formato: Artigo
Idioma:Inglês
Publicado: 2014
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4286435/
https://ncbi.nlm.nih.gov/pubmed/25482540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2014.10.010
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