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Structural Basis for the Recognition of Mycolic Acid Precursors by KasA, a Condensing Enzyme and Drug Target from Mycobacterium Tuberculosis

The survival of Mycobacterium tuberculosis depends on mycolic acids, very long α-alkyl-β-hydroxy fatty acids comprising 60–90 carbon atoms. However, despite considerable efforts, little is known about how enzymes involved in mycolic acid biosynthesis recognize and bind their hydrophobic fatty acyl s...

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書誌詳細
主要な著者: Schiebel, Johannes, Kapilashrami, Kanishk, Fekete, Agnes, Bommineni, Gopal R., Schaefer, Christin M., Mueller, Martin J., Tonge, Peter J., Kisker, Caroline
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837160/
https://ncbi.nlm.nih.gov/pubmed/24108128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.511436
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