Conditional Depletion of KasA, a Key Enzyme of Mycolic Acid Biosynthesis, Leads to Mycobacterial Cell Lysis

Inhibition or inactivation of InhA, a fatty acid synthase II (FASII) enzyme, leads to mycobacterial cell lysis. To determine whether inactivation of other enzymes of the mycolic acid-synthesizing FASII complex also leads to lysis, we characterized the essentiality of two β-ketoacyl-acyl carrier prot...

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Bibliografiske detaljer
Main Authors: Bhatt, Apoorva, Kremer, Laurent, Dai, Annie Z., Sacchettini, James C., Jacobs, William R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2005
Fag:
Genetics and Molecular Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1280301/
https://ncbi.nlm.nih.gov/pubmed/16267284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.187.22.7596-7606.2005
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