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EGFR-TKI, Erlotinib, Causes Hypomagnesemia, Oxidative Stress and Cardiac Dysfunction: Attenuation by NK-1 Receptor Blockade
To determine whether the EGFR tyrosine kinase inhibitor, erlotinib may cause hypomagnesemia, inflammation and cardiac stress, erlotinib was administered to rats (10 mg/kg/day) for 9 weeks. Plasma magnesium decreased progressively between 3-9 weeks (-9 to -26%). Modest increases in plasma substance P...
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| Pubblicato in: | J Cardiovasc Pharmacol |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4286425/ https://ncbi.nlm.nih.gov/pubmed/25343568 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FJC.0000000000000163 |
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