Nanoscale stiffness topography reveals structure and mechanics of the transport barrier in intact nuclear pore complexes

The nuclear pore complex (NPC) is the gate for transport between the cell nucleus and the cytoplasm. Small molecules cross the NPC by passive diffusion, but molecules larger than ~5 nm must bind to nuclear transport receptors to overcome a selective barrier within the NPC(1). Whilst the structure an...

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Publicado en:Nat Nanotechnol
Autores principales: Bestembayeva, Aizhan, Kramer, Armin, Labokha, Aksana A., Osmanović, Dino, Liashkovich, Ivan, Orlova, Elena V., Ford, Ian J., Charras, Guillaume, Fassati, Ariberto, Hoogenboom, Bart W.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4286247/
https://ncbi.nlm.nih.gov/pubmed/25420031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nnano.2014.262
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