Nanoscale stiffness topography reveals structure and mechanics of the transport barrier in intact nuclear pore complexes

The nuclear pore complex (NPC) is the gate for transport between the cell nucleus and the cytoplasm. Small molecules cross the NPC by passive diffusion, but molecules larger than ~5 nm must bind to nuclear transport receptors to overcome a selective barrier within the NPC(1). Whilst the structure an...

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Gepubliceerd in:Nat Nanotechnol
Hoofdauteurs: Bestembayeva, Aizhan, Kramer, Armin, Labokha, Aksana A., Osmanović, Dino, Liashkovich, Ivan, Orlova, Elena V., Ford, Ian J., Charras, Guillaume, Fassati, Ariberto, Hoogenboom, Bart W.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4286247/
https://ncbi.nlm.nih.gov/pubmed/25420031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nnano.2014.262
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