HIV-1 Reverse Transcriptase Can Simultaneously Engage its DNA/RNA Substrate at both the DNA Polymerase and RNase H Active Sites: Implications for RNase H Inhibition

Reverse transcriptase (RT) of the human immunodeficiency virus (HIV) possesses DNA polymerase and ribonuclease (RNase) H activities. Although the nucleic acid binding cleft separating these domains can accommodate structurally-diverse duplexes, it is currently unknown whether regular DNA/RNA hybrids...

Full description

Saved in:

Bibliographic Details
Published in:	J Mol Biol
Main Authors:	Beilhartz, Greg L., Wendeler, Michaela, Baichoo, Noel, Rausch, Jason, Le Grice, Stuart, Götte, Matthias
Format:	Artigo
Language:	Inglês
Published:	2009
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4285699/ https://ncbi.nlm.nih.gov/pubmed/19289131 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.03.025
Tags:	Add Tag No Tags, Be the first to tag this record!

HIV-1 Reverse Transcriptase Can Simultaneously Engage its DNA/RNA Substrate at both the DNA Polymerase and RNase H Active Sites: Implications for RNase H Inhibition

Similar Items