HIV-1 Reverse Transcriptase Can Simultaneously Engage its DNA/RNA Substrate at both the DNA Polymerase and RNase H Active Sites: Implications for RNase H Inhibition

Reverse transcriptase (RT) of the human immunodeficiency virus (HIV) possesses DNA polymerase and ribonuclease (RNase) H activities. Although the nucleic acid binding cleft separating these domains can accommodate structurally-diverse duplexes, it is currently unknown whether regular DNA/RNA hybrids...

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Publicado en:J Mol Biol
Autores principales: Beilhartz, Greg L., Wendeler, Michaela, Baichoo, Noel, Rausch, Jason, Le Grice, Stuart, Götte, Matthias
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4285699/
https://ncbi.nlm.nih.gov/pubmed/19289131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.03.025
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