Efficacy of Nelfinavir as Monotherapy in Refractory Adenoid Cystic Carcinoma: Results of a Phase II Clinical Trial

BACKGROUND: Adenoid cystic carcinoma (ACCs) are malignant salivary gland tumors noteworthy for high rates of late failure with limited salvage therapy options. We have previously shown increased Akt signaling is common in ACC and the HIV protease inhibitor nelfinavir (NFV) inhibits in vitro tumor gr...

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Detaylı Bibliyografya
Yayımlandı:Head Neck
Asıl Yazarlar: Hoover, Andrew C, Milhem, Mohammed M, Anderson, Carryn M, Sun, Wenqing, Smith, Brian J, Hoffman, Henry T, Buatti, John M
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4285572/
https://ncbi.nlm.nih.gov/pubmed/24596143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hed.23664
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