The multi-functional sorting protein PACS-2 regulates SIRT1-mediated deacetylation of p53 to modulate p21-dependent cell cycle arrest

SIRT1 regulates the DNA damage response by deacetylating p53, thereby repressing p53 transcriptional output. Here we demonstrate that the sorting protein PACS-2 regulates SIRT1-mediated deacetylation of p53 to modulate the DNA damage response. PACS-2 knockdown cells failed to efficiently undergo p53...

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Pubblicato in:Cell Rep
Autori principali: Atkins, Katelyn M., Thomas, Laura L., Barroso-González, Jonathan, Thomas, Laurel, Auclair, Sylvain, Yin, Jun, Kang, Hyeog, Chung, Jay H., Dikeakos, Jimmy D., Thomas, Gary
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4285392/
https://ncbi.nlm.nih.gov/pubmed/25159152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.07.049
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