The sorting protein PACS-2 promotes ErbB signalling by regulating recycling of the metalloproteinase ADAM17

The metalloproteinase ADAM17 activates ErbB signalling by releasing ligands from the cell surface, a key step underlying epithelial development, growth, and tumour progression. However, mechanisms acutely controlling ADAM17 cell-surface availability to modulate the extent of ErbB ligand release are...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Dombernowsky, Sarah Louise, Samsøe-Petersen, Jacob, Petersen, Camilla Hansson, Instrell, Rachael, Hedegaard, Anne-Mette Bornhardt, Thomas, Laurel, Atkins, Katelyn Mae, Auclair, Sylvain, Albrechtsen, Reidar, Mygind, Kasper Johansen, Fröhlich, Camilla, Howell, Michael, Parker, Peter, Thomas, Gary, Kveiborg, Marie
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4481878/
https://ncbi.nlm.nih.gov/pubmed/26108729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8518
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