Low intensity focused ultrasound (LOFU) modulates unfolded protein response and sensitizes prostate cancer to 17AAG

The hypoxic tumor microenvironment generates oxidative Endoplasmic Reticulum (ER) stress, resulting in protein misfolding and unfolded protein response (UPR). UPR induces several molecular chaperones including heat-shock protein 90 (HSP90), which corrects protein misfolding and improves survival of...

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Publicat a:Oncoscience
Autors principals: Saha, Subhrajit, Bhanja, Payel, Partanen, Ari, Zhang, Wei, Liu, Laibin, Tomé, Wolfgang, Guha, Chandan
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2014
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4284617/
https://ncbi.nlm.nih.gov/pubmed/25594042
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