Allosteric activation of ADAMTS13 by von Willebrand factor

The metalloprotease ADAMTS13 cleaves von Willebrand factor (VWF) within endovascular platelet aggregates, and ADAMTS13 deficiency causes fatal microvascular thrombosis. The proximal metalloprotease (M), disintegrin-like (D), thrombospondin-1 (T), Cys-rich (C), and spacer (S) domains of ADAMTS13 reco...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Muia, Joshua, Zhu, Jian, Gupta, Garima, Haberichter, Sandra L., Friedman, Kenneth D., Feys, Hendrik B., Deforche, Louis, Vanhoorelbeke, Karen, Westfield, Lisa A., Roth, Robyn, Tolia, Niraj Harish, Heuser, John E., Sadler, J. Evan
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2014
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4284596/
https://ncbi.nlm.nih.gov/pubmed/25512528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1413282112
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