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STAT3 promotes survival of mutant photoreceptors in inherited photoreceptor degeneration models

Inherited photoreceptor degenerations (IPDs), a group of incurable progressive blinding diseases, are caused by mutations in more than 200 genes, but little is known about the molecular pathogenesis of photoreceptor (PR) death. Increased retinal expression of STAT3 has been observed in response to m...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Jiang, Ke, Wright, Katherine L., Zhu, Ping, Szego, Michael J., Bramall, Alexa N., Hauswirth, William W., Li, Qiuhong, Egan, Sean E., McInnes, Roderick R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2014
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4284576/
https://ncbi.nlm.nih.gov/pubmed/25512545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1411248112
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