Endothelin-2-Mediated Protection of Mutant Photoreceptors in Inherited Photoreceptor Degeneration

Expression of the Endothelin-2 (Edn2) mRNA is greatly increased in the photoreceptors (PRs) of mouse models of inherited PR degeneration (IPD). To examine the role of Edn2 in mutant PR survival, we generated Edn2(−/−) mice carrying homozygous Pde6b(rd1) alleles or the Tg(RHO P347S) transgene. In the...

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Autori principali: Bramall, Alexa N., Szego, Michael J., Pacione, Laura R., Chang, Inik, Diez, Eduardo, D'Orleans-Juste, Pedro, Stewart, Duncan J., Hauswirth, William W., Yanagisawa, Masashi, McInnes, Roderick R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585171/
https://ncbi.nlm.nih.gov/pubmed/23469133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0058023
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