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STAT3 promotes survival of mutant photoreceptors in inherited photoreceptor degeneration models

Inherited photoreceptor degenerations (IPDs), a group of incurable progressive blinding diseases, are caused by mutations in more than 200 genes, but little is known about the molecular pathogenesis of photoreceptor (PR) death. Increased retinal expression of STAT3 has been observed in response to m...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Jiang, Ke, Wright, Katherine L., Zhu, Ping, Szego, Michael J., Bramall, Alexa N., Hauswirth, William W., Li, Qiuhong, Egan, Sean E., McInnes, Roderick R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4284576/
https://ncbi.nlm.nih.gov/pubmed/25512545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1411248112
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