STAT3 promotes survival of mutant photoreceptors in inherited photoreceptor degeneration models

Inherited photoreceptor degenerations (IPDs), a group of incurable progressive blinding diseases, are caused by mutations in more than 200 genes, but little is known about the molecular pathogenesis of photoreceptor (PR) death. Increased retinal expression of STAT3 has been observed in response to m...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Jiang, Ke, Wright, Katherine L., Zhu, Ping, Szego, Michael J., Bramall, Alexa N., Hauswirth, William W., Li, Qiuhong, Egan, Sean E., McInnes, Roderick R.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2014
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4284576/
https://ncbi.nlm.nih.gov/pubmed/25512545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1411248112
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