Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson–Gilford progeria syndrome

Hutchinson–Gilford progeria syndrome (HGPS) is a premature aging disorder, commonly caused by a point mutation in the lamin A gene that results in a protein lacking 50 aa near the C terminus, denoted LAΔ50. Here we show by light and electron microscopy that HGPS is associated with significant change...

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Detalhes bibliográficos
Main Authors: Goldman, Robert D., Shumaker, Dale K., Erdos, Michael R., Eriksson, Maria, Goldman, Anne E., Gordon, Leslie B., Gruenbaum, Yosef, Khuon, Satya, Mendez, Melissa, Varga, Renée, Collins, Francis S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC428455/
https://ncbi.nlm.nih.gov/pubmed/15184648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0402943101
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