The SAGA histone deubiquitinase module controls yeast replicative lifespan via Sir2 interaction

We have analyzed the yeast replicative lifespan of a large number of ORF deletions. Here we report that strains lacking genes SGF73, SGF11, and UBP8, encoding SAGA/SLIK complex histone deubiquitinase module (DUBm) components, are exceptionally long-lived. Strains lacking other SAGA/SALSA components,...

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Publicat a:Cell Rep
Autors principals: McCormick, Mark A., Mason, Amanda G., Guyenet, Stephan J., Dang, Weiwei, Garza, Renee M., Ting, Marc K., Moller, Rick M., Berger, Shelley L., Kaeberlein, Matt, Pillus, Lorraine, La Spada, Albert R., Kennedy, Brian K.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4284099/
https://ncbi.nlm.nih.gov/pubmed/25043177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.06.037
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