Histone H4 lysine-16 acetylation regulates cellular lifespan

Cells undergoing developmental processes are characterized by persistent non-genetic alterations in chromatin, termed epigenetic changes, represented by distinct patterns of DNA methylation and histone post-translational modifications. Sirtuins, a group of conserved NAD(+)-dependent deacetylases or...

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Autori principali: Dang, Weiwei, Steffen, Kristan K., Perry, Rocco, Dorsey, Jean A., Johnson, F. Brad, Shilatifard, Ali, Kaeberlein, Matt, Kennedy, Brian K., Berger, Shelley L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2702157/
https://ncbi.nlm.nih.gov/pubmed/19516333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08085
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