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TPX2 Impacts Acetylation of Histone H4 at Lysine 16: Implications for DNA Damage Response

During interphase, the spindle assembly factor TPX2 is compartmentalized in the nucleus where its roles remain largely uncharacterized. Recently, we found that TPX2 regulates the levels of serine 139-phosphoryated H2AX (γ-H2AX) at chromosomal breaks induced by ionizing radiation. Here, we report tha...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Neumayer, Gernot, Nguyen, Minh Dang
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217740/
https://ncbi.nlm.nih.gov/pubmed/25365214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0110994
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