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Data-driven treatment selection for seamless phase II/III trials incorporating early-outcome data

Seamless phase II/III clinical trials are conducted in two stages with treatment selection at the first stage. In the first stage, patients are randomized to a control or one of k > 1 experimental treatments. At the end of this stage, interim data are analysed, and a decision is made concerning w...

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Publicado en:Pharm Stat
Autores principales: Kunz, Cornelia Ursula, Friede, Tim, Parsons, Nick, Todd, Susan, Stallard, Nigel
Formato: Artigo
Lenguaje:Inglês
Publicado: BlackWell Publishing Ltd 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4283755/
https://ncbi.nlm.nih.gov/pubmed/24789367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pst.1619
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