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Flexible selection of a single treatment incorporating short‐term endpoint information in a phase II/III clinical trial

Seamless phase II/III clinical trials in which an experimental treatment is selected at an interim analysis have been the focus of much recent research interest. Many of the methods proposed are based on the group sequential approach. This paper considers designs of this type in which the treatment...

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Détails bibliographiques
Publié dans:Stat Med
Auteurs principaux: Stallard, Nigel, Kunz, Cornelia Ursula, Todd, Susan, Parsons, Nicholas, Friede, Tim
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4745001/
https://ncbi.nlm.nih.gov/pubmed/26112909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.6567
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