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Blinded versus unblinded estimation of a correlation coefficient to inform interim design adaptations
Regulatory authorities require that the sample size of a confirmatory trial is calculated prior to the start of the trial. However, the sample size quite often depends on parameters that might not be known in advance of the study. Misspecification of these parameters can lead to under‐ or overestima...
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| Publicado no: | Biom J |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5412911/ https://ncbi.nlm.nih.gov/pubmed/27886393 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bimj.201500233 |
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