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Blinded versus unblinded estimation of a correlation coefficient to inform interim design adaptations

Regulatory authorities require that the sample size of a confirmatory trial is calculated prior to the start of the trial. However, the sample size quite often depends on parameters that might not be known in advance of the study. Misspecification of these parameters can lead to under‐ or overestima...

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Bibliographische Detailangaben
Veröffentlicht in:Biom J
Hauptverfasser: Kunz, Cornelia U., Stallard, Nigel, Parsons, Nicholas, Todd, Susan, Friede, Tim
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5412911/
https://ncbi.nlm.nih.gov/pubmed/27886393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bimj.201500233
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